CV

(updated to 11-OCT-2023)

Education

B.S. in Agronomy, Zhejiang University, 2015
Ph.D in Statistical Genetics, The University of Queensland, 2021

Work experience

2021.5 - now: Postdoc Scientist
- Garvan Institute of Medical Research, NSW, Australia
- Supervisor: Professor Joseph Powell
- Duties included:
  - Analyzed the scRNA-seq data of ~1 million peripheral blood mononuclear cell from ~1,000 individuals
  - Identified genetic variants associated with intra-individual variance on the gene expression level
  - Integrated multi-omics data to discover novel biomarkers for autoimmune diseases
2016.10 - 2021.4: PhD student
- The University of Queensland, QLD, Australia
- Supervisor: Professor Jian Yang
- Duties included:
  - Integrated multi-omics data to prioritize functional genes and regulatory mechanisms of type 2 diabetes
  - Investigated how misreported and longitudinal changes bias the genetic analysis of behavioral traits
  - Evaluated the causal association between human behaviors and complex diseases
  - Improved the algorithm and co-developed an R software package (GSMR2) for Mendelian Randomization analysis
2015.5 - 2016.5: Casual Research Assistant
- Zhejiang University, ZJ, China
- Supervisor: Professor Jun Zhu
- Duties included:
  - Analyzed the multi-omics data to detect SNPs and eQTLs associated with startle behavior
  - Investigated the evolutionary conservation of key genes and pathways between fruit fly and human
2013.7 - 2013.8: Summer Research Assistant
- University of Illinois at Urbana-Champaign, IL, the United States
- Supervisor: Professor Mohammad Babadoost
- Duties included:
  - Measured the sensitivities of a list of Phytophthora capsici isolates from pumpkins in Illinois to a fungicide dimethomorph (DMT) by determining EC50 of colony diameter growth

Skills

Programming: R, Python, bash scripting
High Performance Computing: SGE and PBS systems
Software: Seurat, PLINK, GCTA, BOLT-LMM, SAIGE, LD score regression, MatrixeQTL/TensorQTL, SMR, coloc

Publications

Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes

Angli Xue*, Yang Wu*, Zhihong Zhu, Futao Zhang, Kathryn E Kemper, Zhili Zheng, …, Jian Zeng#, Jian Yang#. Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes. Nature Communications. 12, 6450 (2018).

Genome-wide analyses of behavioural traits are subject to bias by misreports and longitudinal changes

Angli Xue, Longda Jiang, Zhihong Zhu, Naomi R. Wray, Peter M. Visscher, Jian Zeng, Jian Yang. Genome-wide analyses of behavioral traits are subject to bias by misreports and longitudinal changes. Nature Communications. 12, 6450 (2021).

Pitfalls and opportunities for applying latent variables in single-cell eQTL analyses

Angli Xue#, Seyhan Yazar, Drew Neavin, Joseph E. Powell#. "Pitfalls and opportunities for applying latent variables in single-cell eQTL analyses". Genome Biology. 24.1 (2023): 1-11.

Awards

2021 DeLill Nasser Award for Professional Development in Genetics, Genetics Society of America
2020 Chinese Scholarship Council Award for Outstanding Students Abroad
2020 UQ IMB Writing-up Award
2019 UQ IMB Travel Award for International Conference
2018 UQ IMB Research Higher Degree Top-up Scholarships
2018 Outstanding Contribution in Reviewing Award, EBioMedicine Journal
2016 University of Queensland International Scholarship (full tuition and living stipend)
2015 Outstanding Thesis Award for Bachelor’s Degree, Zhejiang University
2015 Summer Program Scholarship of the Council for Higher Education, the Government of Israel
2014 Scholarship for Outstanding Performance in Research and Innovation, Zhejiang University
2013 Gold Medal & Best Biobrick Measurement Approach, International Genetically Engineered Machine (iGEM) Competition, Asian region

Service and leadership

Team co-lead in THE SYSTEMS IMMUNOLOGY HACKATHON by OzSinglCell and ASI (2022 - now)
Guest Editor for Special Issue “Genetic Architecture of Human Complex Diseases” for journal Genes (2023 - now)
Regular reviewer panel in the Statistical Genetics & Genomics section for the journal GENETICS (2019 - 2022)
Ad hoc reviewer for Nature Medicine, Nature Human Behavior, Nucleic Acids Research, Diabetes, EBioMedicine, Genetics, G3: Genes,Genomes,Genetics, NAR genomics and bioinformatics, Human Genetics, Clinical Obesity, Journal of Human Genetics.